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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PNKP All Species: 11.52
Human Site: S349 Identified Species: 23.03
UniProt: Q96T60 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.36
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96T60 NP_009185.2 521 57076 S349 D P R T V S R S G P L C L P E
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001115581 521 57143 S349 D P R T L S R S G P L C L P E
Dog Lupus familis XP_541488 521 57419 S349 D P R T V S P S G P L C L P E
Cat Felis silvestris
Mouse Mus musculus Q9JLV6 522 57205 A348 D P R T I S S A G P L Y L P E
Rat Rattus norvegicus Q8K4H4 329 37701 D164 G L K I S M K D P K M Q V Y K
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis Q7T287 347 39626 D182 D L K V S M Q D P T M Q V F K
Zebra Danio Brachydanio rerio P61799 324 36503 D159 G L K A S M Q D P K M Q V Y K
Tiger Blowfish Takifugu rubipres P61800 356 40172 D191 G L K A S M Q D P E M Q V Y K
Fruit Fly Dros. melanogaster NP_649792 523 58549 Q349 E P T S V Q D Q V S L L D P D
Honey Bee Apis mellifera XP_624633 492 57193 K318 E L P I F N P K N L S N K E I
Nematode Worm Caenorhab. elegans Q19683 407 46169 D242 I T E L E P H D A Q L K S S E
Sea Urchin Strong. purpuratus XP_785301 905 98367 S729 D P T T V S T S T P L F H P P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 96.7 86.5 N.A. 80.8 21.3 N.A. N.A. N.A. 20.9 20.3 21.6 39 36.6 36.8 31.2
Protein Similarity: 100 N.A. 98 90.7 N.A. 88.3 35.1 N.A. N.A. N.A. 36.2 33.9 37 55.8 54.3 50.4 41.5
P-Site Identity: 100 N.A. 93.3 93.3 N.A. 73.3 0 N.A. N.A. N.A. 6.6 0 0 26.6 0 13.3 60
P-Site Similarity: 100 N.A. 100 93.3 N.A. 86.6 33.3 N.A. N.A. N.A. 40 33.3 33.3 46.6 13.3 13.3 60
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 17 0 0 0 9 9 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 25 0 0 0 % C
% Asp: 50 0 0 0 0 0 9 42 0 0 0 0 9 0 9 % D
% Glu: 17 0 9 0 9 0 0 0 0 9 0 0 0 9 42 % E
% Phe: 0 0 0 0 9 0 0 0 0 0 0 9 0 9 0 % F
% Gly: 25 0 0 0 0 0 0 0 34 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 9 0 0 0 0 0 9 0 0 % H
% Ile: 9 0 0 17 9 0 0 0 0 0 0 0 0 0 9 % I
% Lys: 0 0 34 0 0 0 9 9 0 17 0 9 9 0 34 % K
% Leu: 0 42 0 9 9 0 0 0 0 9 59 9 34 0 0 % L
% Met: 0 0 0 0 0 34 0 0 0 0 34 0 0 0 0 % M
% Asn: 0 0 0 0 0 9 0 0 9 0 0 9 0 0 0 % N
% Pro: 0 50 9 0 0 9 17 0 34 42 0 0 0 50 9 % P
% Gln: 0 0 0 0 0 9 25 9 0 9 0 34 0 0 0 % Q
% Arg: 0 0 34 0 0 0 17 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 9 34 42 9 34 0 9 9 0 9 9 0 % S
% Thr: 0 9 17 42 0 0 9 0 9 9 0 0 0 0 0 % T
% Val: 0 0 0 9 34 0 0 0 9 0 0 0 34 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 9 0 25 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _